Logical Regulatory Graphs

Informally, a Logical Regulatory Graph (LRG) is a directed labelled multigraph representing interactions (the edges) between genes (the nodes). Each interaction involves two genes, the source and the target, becoming active whenever its source reaches a given level.

The activation level of each component is defined by a regulatory function comprising parameters relative to all regulators of this component.

For a more formal definition see [1] or [ 2 ] .

1

Dynamically consistent reduction of logical regulatory graphs. A. Naldi, E. Remy, D. Thieffry, C. Chaouiya. Theoretical Computer Science 412:2207--2218 (2011).

2

Dynamical roles of biological regulatory circuits. D. Thieffry. Briefings in Bioinformatics 8:220--225 (2007).