Budding yeast cell cycle (Orlando et al. 2008)

Taxon: Yeast | Budding yeast
Process: Cell cycle
Submitter: Adrien Fauré (C. Chaouiya)

Supporting paper: Fauré, Adrien and Thieffry, Denis (2009). Logical modelling of cell cycle control in eukaryotes: a comparative study. Molecular BioSystems. 10.1039/b907562n

Model file(s) Description(s)
buddingYeastOrlando2008.zginml Budding yeast cell cycle (Orlando et al. 2008)

Summary:
This model is a direct transcription of the Boolean model published by Orlando et al. 1. Synchronous simulation of this model yields a cyclic attractor gathering most trajectories in the state transition graph, which is robust to parameter choice, as reported in 1. However, asynchronous simulations all lead to a stable state with all variables OFF, whatever the parameter set proposed by the authors, indicating that the oscillations observed in the synchronous simulations may not be sustained. See 2 for more details.

TODO

  1. David A. Orlando, Charles Y. Lin, Allister Bernard, Jean Y. Wang, Joshua E. S. Socolar, Edwin S. Iversen, Alexander J. Hartemink, and Steven B. Haase. Global control of cell-cycle transcription by coupled cdk and network oscillators. Nature, 453(7197):944–947, May 2008. doi:10.1038/nature06955. ↩↩

  2. Adrien Fauré and Denis Thieffry. Logical modelling of cell cycle control in eukaryotes: a comparative study. Molecular BioSystems, 5(12):1569, 2009. doi:10.1039/b907562n. ↩