Budding yeast cell cycle (Orlando et al. 2008)
Taxon: Yeast | Budding yeast Process: Cell cycle
Title: Logical modelling of cell cycle control in eukaryotes: a comparative study
Author(s): Fauré, Adrien and Thieffry, Denis
Journal: Molecular BioSystems
Year: 2009
DOI: 10.1039/b907562n
| Model file(s) | Description(s) |
|---|---|
| buddingYeastOrlando2008.zginml | Budding yeast cell cycle (Orlando et al. 2008) |
Summary:
This model is a direct transcription of the Boolean model published by Orlando
et al. 1.
Synchronous simulation of this model yields a cyclic attractor gathering
most trajectories in the state transition graph, which is robust to
parameter choice, as reported in 1.
However, asynchronous simulations all lead to a stable state with all
variables OFF, whatever the parameter set proposed by the authors,
indicating that the oscillations observed in the synchronous
simulations may not be sustained.
See 2 for more details.
TODO
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David A. Orlando, Charles Y. Lin, Allister Bernard, Jean Y. Wang, Joshua E. S. Socolar, Edwin S. Iversen, Alexander J. Hartemink, and Steven B. Haase. Global control of cell-cycle transcription by coupled cdk and network oscillators. Nature, 453(7197):944–947, May 2008. doi:10.1038/nature06955. ↩↩
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Adrien Fauré and Denis Thieffry. Logical modelling of cell cycle control in eukaryotes: a comparative study. Molecular BioSystems, 5(12):1569, 2009. doi:10.1039/b907562n. ↩