Drosophila JAK/STAT Signalling pathway

Taxon: D. melanogaster
Process: Signalling
Submitter: Abibatou MBODJ and Denis THIEFFRY

Supporting paper: Mbodj, Abibatou and Junion, Guillaume and Brun, Christine and Furlong, Eileen E. M. and Thieffry, Denis (2013). Logical modelling of Drosophila signalling pathways. Molecular BioSystems. 10.1039/c3mb70187e

Model file(s) Description(s)
JakStat__Pathway_12Jun2013.zginml GINsim file for Drosophila JAK_STAT Signalling pathway
JAK_STAT_Pathway_Documentation_11May2013.pdf Drosophila JAK_STAT Signalling pathway model documentation

Summary:
In Drosophila, three secreted ligands (OS, UPD2 and UPD3) have been identified for the JAK/STAT pathway. Their binding to the receptor dome induces its homo- dimerization, enabling hop to phosphorylate specific tyrosine residues of the receptor. Consequently, STAT92E is also phosphorylated by HOP, leading to his homo-dimerization and nuclear translocation. In the nucleus, STAT92E binds to target DNA sequences and acts as an activator of transcription of several target genes 1. During Drosophila development, the JAK/STAT pathway is involved in embryonic segmentation, eye development, cell growth, haematopoiesis, and sex determination 2 3. JAK/STAT signalling also plays important roles during spermatogenesis 4 and oogenesis 5 6 3. To study the dynamic of the pathway, we define a set of initial states representative of in vivo situations during JAK/STAT signalling. More precisely, we define a three initial states corresponding to pathway signalling (binding of OS or UPD2 or UPD3) and two initial states corresponding to pathway signalling in the presence of an inhibitor (SOCS44A or BRWD3) and one initial state corresponding to non signalling conditions (no binding of ligands).

  1. X Hou. The jak-stat pathway in drosophila. Trends in Genetics, 13(3):105–110, March 1997. doi:10.1016/s0168-9525(97)01006-8. ↩

  2. Hong Luo and Charles R. Dearolf. The jak/stat pathway and drosophila development. BioEssays, 23(12):1138–1147, November 2001. doi:10.1002/bies.10016. ↩

  3. Aaron N. Johnson, Mayssa H. Mokalled, Tom N. Haden, and Eric N. Olson. Jak/stat signaling regulates heart precursor diversification indrosophila. Development, 138(21):4627–4638, November 2011. doi:10.1242/dev.071464. ↩↩

  4. Amy A. Kiger, D. Leanne Jones, Cordula Schulz, Madolyn B. Rogers, and Margaret T. Fuller. Stem cell self-renewal specified by jak-stat activation in response to a support cell cue. Science, 294(5551):2542–2545, December 2001. doi:10.1126/science.1066707. ↩

  5. Natalie Denef and Trudi Schüpbach. Patterning: jak-stat signalling in the drosophila follicular epithelium. Current Biology, 13(10):R388–R390, May 2003. doi:10.1016/s0960-9822(03)00317-8. ↩

  6. Rongwen Xi, Jennifer R. McGregor, and Douglas A. Harrison. A gradient of jak pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental Cell, 4(2):167–177, February 2003. doi:10.1016/s1534-5807(02)00412-4. ↩