Mast cell activation

Taxon: Mammal | Blood cells
Process: Signalling
Submitter: Denis Thieffry

Supporting paper: Niarakis, Anna and Bounab, Yacine and Grieco, Luca and Roncagalli, Romain and Hesse, Anne-Marie and Garin, Jérôme and Malissen, Bernard and Daëron, Marc and Thieffry, Denis (2014). Computational Modeling of the Main Signaling Pathways Involved in Mast Cell Activation. . 10.1007/978-3-319-07911-0_4

Model file(s)	Description(s)
Mast_cell_activation_Annotated_19oct2014.zginml	GINsim model

Summary:
Based on an exhaustive curation of the existing literature and using the software CellDesigner, we have built and annotated a comprehensive molecular map for the FceRI and FcgRIIb signalling pathways, which play a key role in mast cell activation in mammals. Using this map and the logical modelling software GINsim, we have derived a logical model recapitulating the most salient features of mast cell activation. This model can be used to explore the dynamical properties of the system and its responses to different stimuli, in normal or mutant conditions.