Mast cell activation

Taxon: Mammal | Blood cells  Process: Signalling
Title: Computational Modeling of the Main Signaling Pathways Involved in Mast Cell Activation
Author(s): Niarakis, Anna and Bounab, Yacine and Grieco, Luca and Roncagalli, Romain and Hesse, Anne-Marie and Garin, Jérôme and Malissen, Bernard and Daëron, Marc and Thieffry, Denis
Journal:
Year: 2014
DOI: 10.1007/978-3-319-07911-0_4

Model file(s)	Description(s)
Mast_cell_activation_Annotated_19oct2014.zginml	GINsim model

Summary:
Based on an exhaustive curation of the existing literature and using the software CellDesigner, we have built and annotated a comprehensive molecular map for the FceRI and FcgRIIb signalling pathways, which play a key role in mast cell activation in mammals. Using this map and the logical modelling software GINsim, we have derived a logical model recapitulating the most salient features of mast cell activation. This model can be used to explore the dynamical properties of the system and its responses to different stimuli, in normal or mutant conditions.