Lymphoid and myeloid cell specification and transdifferentiation

Taxon: Mammal | Blood cells
Process: Differentiation
Submitter: C. Chaouiya (D. Thieffry)

Supporting paper: Collombet, Samuel and van Oevelen, Chris and Sardina Ortega, Jose Luis and Abou-Jaoudé, Wassim and Di Stefano, Bruno and Thomas-Chollier, Morgane and Graf, Thomas and Thieffry, Denis (2017). Logical modeling of lymphoid and myeloid cell specification and transdifferentiation. Proceedings of the National Academy of Sciences. 10.1073/pnas.1610622114

Model file(s)	Description(s)
Collombet_model_Bcell_Macrophages_PNAS_170215.zginml	GINsim model file

Summary:
Blood cells are derived from a common set of hematopoietic stem cells, which differentiate into more specific progenitors of the myeloid and lymphoid lineages, ultimately leading to differentiated cells. This developmental process is controlled by a complex regulatory network involving cytokines and their receptors, transcription factors and chromatin remodelers. Based on public and novel data from molecular genetic experiments (qPCR, western blots, EMSA), along with genome-wide assays (RNA-seq, ChIP-seq), we defined a logical model recapitulating cytokine-induced differentiation of common progenitors, the effect of various reported gene knock-downs, as well as reprogramming of pre-B cells into macrophages induced by ectopic expression of specific transcription factors.

Note: This model is also available at BioModels database BioModels ID: 1610240000.