Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation
Taxon: Mammal | Human
Process: T-cell activation
Submitter: Aurelien Naldi
Supporting paper: Sánchez-Villanueva, José Antonio and Rodríguez-Jorge, Otoniel and Ramírez-Pliego, Oscar and Rosas Salgado, Gabriela and Abou-Jaoudé, Wassim and Hernandez, Céline and Naldi, Aurélien and Thieffry, Denis and Santana, María Angélica (2019). Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation. PLOS ONE. 10.1371/journal.pone.0226388
Model file(s) | Description(s) |
---|---|
TCR-REDOX-METABOLISM_2019-07-26.zginml | Model of T-cell activation under redox stress |
TCR-REDOX-METABOLISM_2019-07-26_reduced.zginml | The reduced model used for dynamical analysis |
TCell_activation_redox.html | Web page showing the analysis notebook |
TCell_activation_redox.ipynb | Executable analysis notebook |
Summary:
The low response to infection in neonatal T cells contributes to a high
incidence of morbidity and mortality. Here we evaluated the effect of the
cytoplasmic and mitochondrial levels of Reactive Oxygen Species (ROS) of
neonatal CD8+T cells on their low activation. This model captures the
interplay between antigen recognition with ROS and metabolic status in T cell
responses. This model displays alternative stable states, which corresponds to
different cell fates, i.e. quiescent, activated and anergic, depending on ROS
status.
The associated notebook can be loaded using the CoLoMoTo notebook docker image (see http://www.colomoto.org/notebook).