Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation

Taxon: Mammal | Human  Process: T-cell activation
Title: Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation
Author(s): Sánchez-Villanueva, José Antonio and Rodríguez-Jorge, Otoniel and Ramírez-Pliego, Oscar and Rosas Salgado, Gabriela and Abou-Jaoudé, Wassim and Hernandez, Céline and Naldi, Aurélien and Thieffry, Denis and Santana, María Angélica
Journal: PLOS ONE
Year: 2019
DOI: 10.1371/journal.pone.0226388

Model file(s)	Description(s)
TCR-REDOX-METABOLISM_2019-07-26.zginml	Model of T-cell activation under redox stress
TCR-REDOX-METABOLISM_2019-07-26_reduced.zginml	The reduced model used for dynamical analysis
TCell_activation_redox.html	Web page showing the analysis notebook
TCell_activation_redox.ipynb	Executable analysis notebook

Summary:
The low response to infection in neonatal T cells contributes to a high incidence of morbidity and mortality. Here we evaluated the effect of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species (ROS) of neonatal CD8+T cells on their low activation. This model captures the interplay between antigen recognition with ROS and metabolic status in T cell responses. This model displays alternative stable states, which corresponds to different cell fates, i.e. quiescent, activated and anergic, depending on ROS status.

The associated notebook can be loaded using the CoLoMoTo notebook docker image (see http://www.colomoto.org/notebook).