Regulation of p21-dependent senescence-apoptosis switch by the ATM/miR-34a-5p axis in non-small cell lung cancer

Taxon: Mammal
Process: DNA repair | Cell cycle
Submitter: D. Thieffry

Supporting paper: Shantanu Gupta and Daner A. Silveira and Jose Carlos M. Mombach (2020). ATM/miR-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a Boolean model of G1/S checkpoint regulation. FEBS Letter. 10.1002/1873-3468.13615

Model file(s) Description(s)
Gupta_FEBSLetter_2020_Supplementary_File_S1.zginml GINsim model

Summary:
Published by Gupta et al in FEBS Letters in 2020 1, this Boolean model focuses on the regulation of a p21-dependent senescence-apoptosis switch in non-small cell lung cancer, emphasising the roles of two micro-RNAs, as well as of the histone deacetylase HDAC1.

  1. Shantanu Gupta, Daner A. Silveira, and Jose Carlos M. Mombach. Atm/mir-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a boolean model of g1/s checkpoint regulation. FEBS Letter, 594:227–39, October 2020. doi:10.1002/1873-3468.13615. ↩