Regulation of p21-dependent senescence-apoptosis switch by the ATM/miR-34a-5p axis in non-small cell lung cancer
Taxon: Mammal Process: DNA repair | Cell cycle
Title: ATM/miR-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a Boolean model of G1/S checkpoint regulation
Author(s): Shantanu Gupta and Daner A. Silveira and Jose Carlos M. Mombach
Journal: FEBS Letter
Year: 2020
DOI: 10.1002/1873-3468.13615
| Model file(s) | Description(s) |
|---|---|
| Gupta_FEBSLetter_2020_Supplementary_File_S1.zginml | GINsim model |
Summary:
Published by Gupta et al in FEBS Letters in 2020 1, this Boolean model focuses on the regulation of a p21-dependent senescence-apoptosis switch in non-small cell lung cancer, emphasising the roles of two micro-RNAs, as well as of the histone deacetylase HDAC1.
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Shantanu Gupta, Daner A. Silveira, and Jose Carlos M. Mombach. Atm/mir-34a-5p axis regulates a p21-dependent senescence-apoptosis switch in non-small cell lung cancer: a boolean model of g1/s checkpoint regulation. FEBS Letter, 594:227–39, October 2020. doi:10.1002/1873-3468.13615. ↩