Differentiation of Monocytes to Dendritic Cells

Taxon: Mammal | Human
Process: Differentiation
Submitter: Aurelien Naldi

Supporting paper: Nuñez-Reza, Karen J. and Naldi, Aurélien and Sánchez-Jiménez, Arantza and Leon-Apodaca, Ana V. and Santana, M. Angélica and Thomas-Chollier, Morgane and Thieffry, Denis and Medina-Rivera, Alejandra (2021). Logical modelling of in vitro differentiation of human monocytes into dendritic cells unravels novel transcriptional regulatory interactions. Interface Focus. 10.1098/rsfs.2020.0061

Model file(s)	Description(s)
Karen_MoDC_27Jan2021.zginml	Model of the differentiation of Monocyte-derived Dendritic Cells

Summary:
This logical model accounts for the differentiation of monocytes into monocyte-derived dendritic cells (moDCs) and macrophages. It recapitulates the main established facts regarding wild-type differentiation of monocytes and macrophages in the presence of CSF2 and/or IL4, as well as the impact of various documented mutations. This model integrates documented regulatory interactions, together with novel interactions predicted from public transcriptomic and epigenomic data, enabling to validate in silico various novel transcriptional regulatory links presumably involved in this differentiation process.